Chemotherapy was potentiated by E7449 and single agent had sizeable antitumor activity in BRCA-deficient xenografts. On top of that, E7449 inhibited Wnt/β-catenin signaling in colon cancer mobile strains, probable via TNKS inhibition. In line with this probability, E7449 stabilized axin and TNKS proteins resulting in β-catenin de-stabilization an
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